An aerosol-based protein inhalant has been shown in trials to reduce the risk of death from SARS-CoV-2 and reduce the chance of developing serious symptoms by 79% compared to patients given a placebo.
Results also showed that patients were more than twice as likely to make a full recovery from Covid-19, meaning they had no lasting respiratory weakness or other damages.
The new drug called SNG001 is an inhalant of the naturally-occurring protein called interferon beta, and arose out of research conducted at the University of Southampton. The British biotech firm Synairgen, co-founded by three of the university’s professors, tested the treatment on 100 hospitalized COVID-19 patients (and 120 who were at home) in a randomized controlled trial spanning a period from March to May.
When inhaled directly into the lungs, interferon beta activates a powerful immune response. Interferon beta was a prime protein candidate for treatment testing because Covid-19 suppresses the body’s natural production of interferon beta which helps form the inherent protection against the spreading virus in the body.
“We are all delighted with the trial results announced today, which showed that SNG001 greatly reduced the number of hospitalized COVID-19 patients who progressed from ‘requiring oxygen’ to ‘requiring ventilation’,” said Richard Marsden, CEO of Synairgen.
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“It also showed that patients who received SNG001 were at least twice as likely to recover to the point where their everyday activities were not compromised through having been infected by SARS-CoV-2. This assessment of SNG001 in COVID-19 patients could signal a major breakthrough in the treatment of hospitalized COVID-19 patients.”
Professor Stephen Holgate, one of Synairgen’s co-founders, described it as having “huge potential” for restoring the natural immune system response in a patient’s lungs.
He added that not only does SNG001 help the lungs combat Covid-19, but it could become a more important treatment than any future vaccines which may have to be re-engineered as the virus mutates in the future.
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“Recognizing that SARS-CoV-2 is known to have evolved to evade the initial antiviral response of the lung, our inhaled treatment of giving high local concentrations of interferon beta restores the lungs’ ability to neutralize the virus, or any mutation of the virus or co-infection with another respiratory virus such as influenza or RSV, as could be encountered in the winter if there is a resurgence of COVID-19,” noted Holgate.
The Phase II trial was relatively small, and the results have not been peer reviewed for error or bias. The company would require regulatory approval before SNG001 can be commercially marketed, but if approved the treatment could revolutionize the way viral respiratory infections such as MERS, SARS, and Covid-19 are treated.
“Our efforts are now focused on working with the regulators and other key groups to progress this potential COVID-19 treatment as rapidly as possible,” said Marsden.
Last month, a research team at the University of Oxford announced they had successfully reduced the risk of death among seriously ill patients by administering the commonly available steroid dexamethasone.
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